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NEW PRODUCTS FOR PSORIASIS TREATMENT

- PSOROL AND PHYTOPSOROL -

Psoriasis
, a severe skin disease, is affecting at present ca. 3% of the world population, even 6-8% in the Nordic countries, and does not beneficiate as yet of a definitive cure.

It can develop at any age. It starts with one or two lesions and it extends all over the body, evolving from a cosmetic problem to disfigurement.

The general health is not affected, except the case in which psoriasis is associated with arthritis. It is not an exaggeration to say that psoriasis can ruin lives form the physical, emotional and material point of view.

The disease has usually a slow evolution, following the typical pattern of development and remission.

It generally appears as patches of raised red skin covered by a flaky white buildup. These lesions cure without traces and without affecting the hair. The nails are sometimes badly affected. Some patients may develop psoriasis on the site of skin injuries (Koebner response).

The usual locations for psoriasis are: bony protuberances (knee, elbow, lower back), scalp, external ears, eyebrows, buttocks, and occasionally generalized on the trunk.

Some cases are associated with severe arthritis such as rheumatic arthritis. This disease is not contagious (catching).

Clinical studies showed that psoriasis could be triggered by numerous factors such as diet, physical and emotional stress, nervous shocks. Certain people are genetically more likely to develop psoriasis but it can be triggered also by infectious diseases, excessive cholesterol, emotional and physiological stress, alcohol and a certain diet.

In order to develop a specific therapy for this disease it is important to understand the processes that psoriatic skin cells are based upon.

In the normal skin, the skin cells mature and are shed about every 28 days, while the psoriatic cells move to the surface of the skin over 3-4 days, approximately 9 times faster. The body can't shed the skin cells fast enough and this process results in patches also called "lesions", that are an inadequate maturation. The cause for this rapid and uncontrolled growth of epithelial cells, a characteristic of psoriasis, is still unknown. Many of psoriasis treatments are oriented towards the removing of the plaques so that no suffering would appear.

The treatments known up to now use corticosteroids, retinoids, methrotrexate (cytostatics) and other chemicals that lower the symptoms, but at what costs?

These treatments are extern but also intern and they are not related to the factors which are actually causing the disease. A list of their side effects is given below.

The corticosteroids may cause infections, advanced osteoporosis, high blood pressure, low level of potassium that leads to the weakening of muscles, low vitamin D and zinc in the blood. Administrated to children it may also interfere with growth.

The retinoids may cause loss of hair, severe gingivitis up to the extraction of teeth, high cholesterol, swelling, drying and irritation of the the eyelids or/and lips, fetus malformations.

Metothrexate, which is used for long-time treatment of psoriasis, causes severe side-effects such as: abnormal function of liver and kidneys, weakening of the immune system, interference with the folic acid metabolism, fatigue, stomach irritations, loss of hair, etc.

Because of these side effects, research has been intensified in order to obtain active principles out of plants for extern and intern treatment.

Thus, ointments have been developed based on Mahonia Aquifolium extracts (that is an ornamental shrub growing on the Pacific Coast of North America). Extracts from the bark and root of Mahonia contain alkaloids which contain powerful antimicrobial and antifungal agents and which inhibit the growth of various cell tumors. Also they are powerful antioxidants which inhibit the growth of abnormal skin cells (keratinocytes) and minimize the inflammation.

Plant extracts have been obtained as juices with a miraculous effect on a large number of maladies, including psoriasis. For example, the juice "Noni" of the plant Morinda Citrifolia which grows in Polynesia, Malaysia, Australia and SouthEast Asia.

The curative effect of such plant extracts seems to be the result of their antioxidant activity centered on the free radicals. Lately, a great number of diseases (cardiovascular diseases, cancer, eye diseases, neurological diseases, and aging problems) are treated with antioxidants. Some of the vitamins (vitamin A, b-carotene, vitamin E, tocotrienols, vitamin C) are also antioxidants.

These antioxidants combine with the free radicals in the human body, such as:

   O2·· - superoxide
   HO· - hydroxyl radical
   HO2· - radical hydroperoxyl
   L· - lipid radical
   LO2· - peroxyl lipid radical
   LO· - alcoxyl lipid radical
   NO2· and NO·: radicals derived from    NO2 and NO
   RS· - thyle radical
   P· - protein radical

or other oxygenated non-radical but very reactive species (pro-oxidants): H2O2, 1O2, LOOH, HOCl, O3, which attacks the cell or interfere in the metabolic processes and lower the immunity of the organism.

Lately a great number of natural antioxidants have been obtained, extracts from various plants and which cover a large spectrum of diseases. They may be not effective on every case, and sometimes the treatment is very long. This can be the result of the extraction method, which may reduce the active species concentration; it can be also the result of the antioxidant efficiency, the organism immunity, etc.

The new products PSOROL and PHYTOPSOROL obtained by the authors of this paper are based on their activity towards stopping the oxidative stress (the deterioration of the cells by the rapid free radicals in the organism). The oxidative stress has serious consequences for the human organisms. It is a contributing factor for several diseases such as cancer, cardiovascular diseases, diseases of the immune system and nervous system, psoriasis, kidney and liver diseases, etc.

The oxidative stress influences also the aging problems - the degenerative processes.

The new products PSOROL and PHYTOPSOROL are protected by five patents, which have been, awarded gold medals in the Brussels, Geneva and Hanover international exhibitions.
These products are based on the mechanism for stopping the oxidative stress, which is presented in the schema below:

where:

   Ro - are the free radicals including the abnormal radical cells;
   A - Oo - is the long life free radical;
   LOo2 - are the lypid-peroxyl radicals
   LOo - are the lipid-alkoxy radicals
   POo - are the protein-alkoxy radicals


The mechanism was first studied on polymers, and it is to be confirmed by studies on biological systems.
The active species of PSOROL is an antioxidant-a stable free radical (A - O·) and the active species of PHYTOPSOROL are bioflavonoids extracted from 6 - 10 Romanian plants.

The two products have been tested on many volunteer patients. The results are shown in figures 1 and 2:

Fig. 1) Before the treatment
Fig. 2) After 5 weeks of treatment

The advantages of the two new products are:

· They stop the oxidative stress
· The treatment is 2-3 times shorter compared to the treatment with other products
· They have no side effects
· They also have a regenerative effect on the skin
· They contribute to the improvement of organism immunity
· Compositions can be formulated for internal administration at much higher efficiency
· The two products fight also against other diseases incurred by the oxidative stress.

Intense research work is carried out to obtain the internal form of PSOROL and PHYTOPSOROL.
That is why we need sponsorship from interested companies for finishing the research, because millions of people from all over the world are waiting for a treatment for psoriasis.

Ph.D. Eng. Diana Andrei and Ph.D. Eng. Constantin Andrei

Institute of Chemical Technology ITEC Brazi
CP 5, OP 1, Ploiesti, ROMANIA
Tel/Fax: 0040 244. 513.020, email: diritec@pbrazi.ro


 
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